Dr Boyle was appointed to Imperial College London as NIHR Clinical Lecturer in 2007, Clinical Senior Lecturer in 2009, Director of the Paediatric Research Unit from 2013 and Clinical Reader from 2017.

Dr Boyle works in a specialist Clinical Research Facility for studies of Children and Young People, with a focus on the development of new ways of preventing, diagnosing and treating inflammatory conditions which affect young people. His research focuses on the primary prevention of allergic diseases, and the need for more robust regulation of the formula industry.

Dr Boyle's clinical trial work has explored several different approaches to preventing allergic diseases. Current studies are focused on the possibility that eczema or food allergy could be prevented by improving infant skin care during the first months of life. He is leading food allergy assessment in the UK BEEP trial, and is updating an individual participant data meta-analysis of infant skin care studies for preventing allergic outcomes.

Dr Boyle's evidence syntheses for the UK Food Standards Agency influenced infant feeding guidance in the UK and internationally. Dr Boyle is Associate Professor of Evidence-Based Dermatology at the University of Nottingham, where he works as Joint Coordinating Editor of the Cochrane Skin Group. He is Senior Editor of the Cochrane Children and Families Network and the Cochrane Mental Health and Neuroscience Network, and Joint Editor in Chief of the journal Clinical and Experimental Allergy.